The honest answer is the solvent, and usually nothing at all, because the solvent is rarely alcohol. Pharmacopoeial convention reserves the word tincture for a liquid preparation obtained by the solvent action of a suitable vehicle, conventionally alcohol of a stated concentration, on plant raw material in fixed proportions. Under that convention a bottle of CBD extract suspended in hemp seed oil is not a tincture at all. The market borrowed the word for the dropper bottle, not for the chemistry.
CBD is practically insoluble in water and dissolves readily in both ethanol and fixed oils, so either solvent works. The licensed cannabidiol oral solution is in fact both: refined sesame oil plus 79 mg of anhydrous ethanol per ml, 10 percent v/v. That is the one cannabidiol liquid whose pharmacokinetics are characterised in detail, and it is neither a pure oil nor a classical tincture.
What does move CBD exposure is food. Eaten alongside a high fat, high calorie meal, cannabidiol reached a 5-fold higher peak concentration and a 4-fold greater total exposure than in the fasted state. That dwarfs any difference anyone has shown between the two labels.
It shows up first in a claim that does not survive testing. Dropper bottles are sold on the premise that holding liquid under the tongue bypasses first pass metabolism. In 8 healthy males given the same CBD oil as sublingual drops or in gelatin capsules, Cmax was 24.0 ng/mL for drops against 28.0 ng/mL for capsules, Tmax was 4 hours in both arms, and exposure was 41.8 against 45.3, with no significant difference. A Tmax of 4 hours is the signature of gastrointestinal absorption, not of the oral mucosa.
It shows up second in formulation, which does matter. Across five oral CBD preparations given at 30 mg each to 15 adults, one liquid reached Tmax at 0.70 hours with a Cmax of 5.57 ng/mL, significantly faster and higher than the rest. The carrier changes exposure even when the route does not.
It shows up third in practicalities. Ethanol stings, brings labelling obligations with it, and rules a product out entirely for some people. An oil has none of those issues, which is why it has become the default dropper format.
The missing piece is the comparison itself. Nobody has run an alcohol based CBD liquid against an oil based one in humans at a matched dose, so a claim that either absorbs better is unsupported. What has been tested is that the dropper adds nothing over a capsule.
Ignore the word and read the label. Check the milligrams of CBD per ml, the ingredient list for the solvent, and whether the headline figure refers to the bottle or to one ml. If the ingredients name ethanol, you have a genuine tincture and should expect a sharp taste and a different drop size. If they name hemp seed oil, MCT or olive oil, you have CBD oil whatever the front label says. Then take it the same way each day with the same kind of meal, because the food effect is several fold and swamps the format question.
Nothing that sounds like a benefit. CBD in a dropper bottle is sold as a food supplement, and no health claim for CBD has been authorised under Regulation (EC) No 1924/2006, so any statement that it supports, aids or relieves anything is not permitted.
What may be stated is what was measured: the milligrams of CBD per ml, the ingredients, the solvent and the batch results. The Food Standards Agency advises that healthy adults take no more than 10 mg of CBD a day, reduced from 70 mg in October 2023.
CBD extracts are novel foods under Regulation (EU) 2015/2283 and require authorisation before sale. The FSA has stated that there are currently no authorised CBD extracts or isolates on the market; products sold legally are those linked to a credible application on the FSA public list, a register of applications in progress rather than approvals.
THC must also fall within the exempt product definition in regulation 2(1) of the Misuse of Drugs Regulations 2001: no component part containing more than 1 mg of the controlled drug, and not recoverable by readily applicable means.
A certificate of analysis settles content, not vocabulary. Every Endoca batch is tested for its cannabinoid profile, reported as milligrams per ml, and screened for pesticides, heavy metals, residual solvents and microbes. The residual solvent panel is the relevant one here, because it shows what remains of the extraction and is how you verify whether a liquid is genuinely alcohol based. Endoca works from its own farm, own land and own extraction, since 2010.
Usually yes. A true tincture is an alcohol extraction, but most products sold as CBD tinctures are CBD extract in a carrier oil in a dropper bottle, which is CBD oil. Check the ingredients for ethanol; if there is none, the two are the same.
The one head to head test says no. In 8 healthy males, the same oil as sublingual drops or swallowed in capsules gave Tmax of 4 hours in both arms and no significant difference in peak concentration or total exposure. A 4 hour peak points to the gut.
Nobody knows, because the comparison has not been run in humans at a matched dose. What is known is that no absolute oral bioavailability has ever been established for CBD in any form, and that the carrier matters more than the dropper does.
No more than 10 mg a day from food for healthy adults, reduced from 70 mg in October 2023. The FSA also advises against CBD for children, for people on medication who have not consulted a medical professional, and for anyone pregnant or breastfeeding.
Millar SA, Stone NL, Yates AS, O’Sullivan SE. A systematic review on the pharmacokinetics of cannabidiol in humans. Front Pharmacol. 2018;9:1365.
Johnson DA, Funnell MP, Heaney LM, et al. Cannabidiol oil ingested as sublingual drops or within gelatin capsules shows similar pharmacokinetic profiles in healthy males. Cannabis Cannabinoid Res. 2024;9(5):e1423-e1432.
Williams NNB, Ewell TR, Abbotts KSS, et al. Comparison of five oral cannabidiol preparations in adult humans: pharmacokinetics, body composition, and heart rate variability. Pharmaceuticals (Basel). 2021;14(1):35.
Epidyolex 100 mg/ml oral solution. Summary of product characteristics, sections 5.2 Pharmacokinetic properties and 6.1 List of excipients. Jazz Pharmaceuticals.
British Pharmacopoeia. Mother tinctures for homoeopathic preparations, Ph. Eur. monograph 2029.
Food Standards Agency and Food Standards Scotland. Food Standards Agency and Food Standards Scotland update consumer advice for CBD, 12 October 2023.
Regulation (EU) 2015/2283 on novel foods, as retained in Great Britain law.
Regulation (EC) No 1924/2006 on nutrition and health claims made on foods, as retained in Great Britain law.
The Misuse of Drugs Regulations 2001, SI 2001/3998, regulation 2(1), definition of exempt product.
Last reviewed 1 October 2026.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.