CBD isolate consists almost entirely of cannabidiol, one of the naturally occurring cannabinoids found in hemp. Unlike THC, CBD does not produce an intoxicating “high.” Researchers continue to investigate how cannabidiol interacts with different molecular pathways in the body, including those associated with the endocannabinoid system.

The endocannabinoid system is a complex network of naturally produced signaling molecules, enzymes and receptors. CBD does not activate the CB1 and CB2 receptors in the same way as THC. Research suggests that its mechanisms are more complex and may involve several different molecular targets. Learn more in this
scientific introduction to the endocannabinoid system.

Because CBD isolate contains cannabidiol without the other cannabinoids and terpenes found in full-spectrum hemp extract, it allows CBD to be studied as an individual compound. Its purity also makes its concentration easier to standardize. However, absorption can vary depending on the formulation, method of use, dose and whether it is taken with food. A
systematic review of CBD pharmacokinetics
found that further research is still needed to fully understand these differences.

Scientific interest in CBD continues to grow, but research involving pharmaceutical preparations or specific clinical doses should not be used to predict the effects of general wellness products. CBD may also interact with certain medicines. The
U.S. Food and Drug Administration
recommends consulting a healthcare professional before using CBD if you take medication, are pregnant or breastfeeding, or have an existing health condition.