You’re about to learn all about
TheEndocannabinoid System.

(most important part of the immune system)

Sounds complicated. But we’ve kept it simple.

Scroll down to absorb the knowledge.

And stay with us - it’ll all be clear by the timeyou finish enjoying the experience.

(if you’re keen, we’ve also added a bunchof resources
to the bottom of this page to help you learn more)

Your Endocannabinoid System helps restore balance in your body by supporting its otherfunctions

That balance is scientifically referred toas “homeostasis”

To getyour head around homeostasis, imagine your body as the surface of a lake

When everything’s alright and the surface is still, you arein a state of homeostasis


But that state is constantly disturbed by everyday challenges, likeworrying

And it’s disturbed by more physical things, like pain

In response, your bodyactivates a number of systems to restore homeostasis

restoring homeostasis

One of those systems is
The Endocannabinoid System (a.k.a. “ECS”)

Your Endocannabinoid System is madefrom...

endocannabiniod enzymes

Enzymes

(they make and break parts of thesystem)

endocannabiniod endocannabinoids

Endocannabinoids

(they deliver messages)

endocannabiniod receptors

Receptors

(they pass messages onto your cells)


When homeostasis is disturbed, the enzyme creates the endocannabinoid

homeostasis disturbed
This binding tells theconnecting cell how to respond to the disturbance, and how to restore homeostasis

Once an endocannabinoid has done its job, it gets broken down again by enzymes

endocannabinoid broken down by enzymes
endocannabinoid broken down by enzymes
These receptors areattached to cells all over your body - including those inside your brain.

maintaining homeostasis
That means that whenendocannabinoids bind with them, they impact lots of different functions - all in the nameof maintaining “homeostasis”

There are two main types of receptor inyour Endocannabinoid System

CB1 helps regulate things like anxiety, fear, appetite

CB1

is particularly keen on helping toregulate things like anxiety, fear, appetite, and energy

CB2 helping to regulate immune and inflammatory responses

CB2

is more interested in helping toregulate immune and inflammatory responses

There are also different types ofendocannabinoid

endocannabiniod enzymes

Anandamide

also known as the “bliss molecule”,binds mostly to CB1

endocannabiniod endocannabinoids

2-AG

binds to both receptors and is mainlyinvolved in supporting immune functions

They’re called “endocannabinoids” because they’re“endogenous” to your body

(which just means you produce themnaturally)

Nowfor the weird part...

Your Endocannabinoid System is also compatible withcomponents of the cannabis plant

These components are known as “phytocannabinoids” as opposed to“endocannabinoids”

Phyto” means plant - as these phytocannabinoidscome from the cannabis plant.

And two of them are pretty highprofile:

thc tetrahydrocannabinol

THC

(a.k.a. “tetrahydrocannabinol”)

cbd cannabidiol

CBD

(a.k.a. “cannabidiol”)

THC mimics theeffects of anandamide - plugging straight into the same receptors

THC mimics the effects of anandamide
But THC acts like asupercharged version of anandamide - overactivating its connecting systems all at once to createa “high” feeling

However, as it’spsychoactive, THC can bring with it some side effects such as anxiety, especially in highdoses

CBD receptors alter how cannabinoids interact with the receptor
Now, CBD doesn’tconnect to your receptors in the same way

Instead, it is believed toalter how other cannabinoids (phyto or endo) interact with the receptor

That meansyou may experience more of the desirable effects of THC when CBD is present

With anandamide,CBD seems to get in the way of the enzyme’s ability to break down anandamide after it hasdone its job

That means you may experiencethe desirable effects of anandamide for longer

experience the desirable effects of anandamide for longer
Meanwhile, CBD isactive at a range of other targets, including CB2, where it helps with anti-inflammatoryfunctions

CBD and CB2 are active where it helps with anti-inflammatory
All of this works together in one of themost complex systems inside your body

A system that we’relearning more about each day.

To get to know more about yourEndocannabinoid System, see the latest summarised studies below...