Scientists have refuted a finding that CBD can turn into THC in the stomach. CBD will not get you high, and that’s that!
A recent in vitro experiment conducted by Merrick and colleagues demonstrated that exposure to an acidic environment could turn CBD into THC. They worried that children using CBD for seizures could experience unwanted side-effects as a result.
Liebert, publishers of the journal Cannabis and Cannabinoid Research, has now published a study that seems to refute this.
CBD can’t convert to THC
Well-known cannabis researchers concluded that even high dosages of CBD taken orally do not cause THC-like effects in humans. They concluded that there is no biosynthetic enzyme path to turn CBD into THC in human physiology.
How did they arrive at this finding? Here’s their reasoning.
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CBD will not get you high. If it could, it would show in drug tests
Should CBD convert to THC in an acidic environment like the stomach, drug tests would show the presence of THC in patients using CBD. This has never happened. On the contrary, evidence supports the opposite effect.
Plasma samples of 14 Huntington disease patients treated with CBD taken over six weeks showed no sign of THC. A further test was conducted on 16 healthy volunteers receiving THC, CBD, and placebo in separate sessions. Only the group that was given THC showed any signs of it in drug tests.
The report argues that high dosages of CBD administered to patients with different conditions in a wide range of studies have not indicated any THC side effects in medical trials.These test subjects did not show psychomotor and cognitive performance impairment, increased heart rate, or dry mouth. These side effects are common in THC-based medical trials.
Psychosis reduced by CBD
The researchers also raised the fact that Parkinson’s disease patients suffering from psychosis administered with CBD seemed to show a reduction in psychosis symptoms. Once again, none of the patients reported typical THC side effects. There is no indication of human conversion of CBD to THC, and no isomerization can take place even when people use high dosages of CBD.
The subjects drawing the attention of Merrick and his associates were children with epilepsy showing drowsiness and fatigue. The researchers wondered if it was because CBD had changed to THC. Test tube experiments seemed to show that this could be possible, but the human body is very different to a test tube. Why were the children drowsy? The new report suggests that CBD given to the children may have been dissolved in methanol, skewing the results.
Clinical data is relevant
The researchers argue that results are only relevant if clinical trials show that they are correct. Their new study shows that in normal gastrointestinal transit, CBD can’t transform into THC. They have based their results on real clinical trials, and so they believe that their finding is relevant while the in vitro research, though interesting, does not apply to human patients.
No reason to believe CBD can become THC
The study concludes that there is absolutely no reason to think that CBD can turn into THC in the human body. Thus, the previous finding, which recommended that researchers should investigate alternatives to oral administration of CBD, is not valid. The bottom line? CBD will not get you high!
Disclaimer: Views expressed here do not necessarily reflect those of Endoca and its staff. This article is not intended to provide medical advice, diagnosis, treatment or cure. Endoca CBD products have not been approved by the US Food and Drug Administration (FDA).