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CBD Could Reduce Your Anxiety

Published on:08/29/16

cbd drops for anxiety, girl with hand in front of her face

CBD and its many therapeutic uses is amassing a whole heap of interest around the world - from both inside and outside the medical profession. And yet, evidence of its efficacy remains largely anecdotal, however a small number of clinical trials have found that CBD decreases symptoms of anxiety.

Quite exciting news for the over 120 million people throughout Europe and the U.S., who suffer from anxiety disorders every day.

If you suffer from anxiety, your life may be a constant, stomach-churning cycle ranging from sleepless nights and depression to panic attacks and extreme phobias. But whatever form it takes, life becomes severely limited when you feel that you must avoid any anxiety-provoking situations.

The standard medical route is to prescribe antidepressants, such as SSRI (Selective Serotonin Reuptake Inhibitors), which can in some circumstances make anxiety symptoms worse. It seems strange then that there is such resistance against the use of CBD for anxiety disorders within the medical profession, particularly with the mounting groundswell of evidence of its effectiveness.


CBD and Anxiety

Cannabidiol (CBD) is one of over 100 natural compounds, also known as cannabinoids, in the Cannabis plant. Most people have heard of THC, or Tetrahydrocannabinol – the one that gets you high, but unfortunately for many people, THC can actually bring on feelings of paranoia and anxiety.

However, CBD is considered non-psychoactive with an increasing number of studies revealing its anti-inflammatory, neuroprotective and antiepileptic qualities. But does CBD help with anxiety?

So far, most research hasn’t made it beyond the science lab with very few human trials taking place. But in the case of CBD and its anxiolytic (anti-anxiety) effects, a number of trials on human subjects have been documented that taking CBD drops for anxiety does in fact help reduce heightened levels of restlessness and stress.

cannabidiol chemical connections

In one test published in Neuropsychopharmacology (1) in 2011, 24 people diagnosed with Social Anxiety Disorder (SAD) were given either CBD or a placebo after which they were asked to perform a simulated public speaking test. According to the trial, just some of CBD’s effects on anxiety included “significantly reduced anxiety, cognitive impairment and discomfort in their speech performance, and significantly decreased alert in their anticipatory speech. The placebo group presented higher anxiety, cognitive impairment, discomfort, and alert levels when compared with the control group.”

Another test, published the same year in the Journal of Psychopharmacology, used neuroimaging on ten people also with SAD who had taken CBD to find out what parts of the brain are affected. Administering CBD for anxiety “was associated with significantly decreased subjective anxiety’ and through the neuroimaging they could see that this was due to CBD’s effect on the ‘activity in limbic and paralimbic brain areas.” The limbic system is largely responsible for our emotional life and formation of memories.

So far, the trials have been few and carried out on a limited number of subjects, but the results are certainly promising.

And it would seem that trials weren’t off the mark. People around the world claim CBD has helped them more than anything else:

I have been having issues with anxiety and mood after quitting antidepressants. Also suffered with back pain and sciatica. All are somewhat of a distant memory. My mood has leveled off. My back pains are not as severe. I use 5 drops twice a day. Great product and great company” - James, Endoca customer.

And like James, Paul has felt the difference CBD can make for controlling both mood and anxiety:

"Provides good relief of anxiety and ‘clears’ the mind bringing about a bit of serenity and calmness. Highly recommended" - Paul, Endoca customer.


The Endocannabinoid System Plays a Vital Role

To understand why CBD for anxiety might help, we first have to understand a bit more about how cannabinoids interact with our bodies. It’s largely due to one of the most important physiological systems in our body, called the Endocannabinoid System (ECS): a vast network of chemical compounds and receptors throughout the body. The primary function of the ECS is to regulate a multitude of functions, from inflammation and pain regulation, immune response, mood, neurogenesis, and neuroplasticity.

Our body produces its own chemicals called endocannabinoids that, when fitting into receptors such as the CB1 and CB2, cause various modulating responses throughout the body. One endocannabinoid called Anandamide is similar to the phytocannabinoid THC found in cannabis. When we produce anandamide, we tend to feel at ease and relaxed, just how many people feel after inhaling cannabis smoke or ingesting cannabis edibles. Both Anandamide and THC fit snugly into the CB1 receptors that are found mostly in the central nervous system, which affects cognition and brain function.


CBD and brain function

cbd and the brain anxiety

CBD, like THC, is a plant cannabinoid (phytocannabinoid), but unlike THC, CBD doesn’t fit directly into any of the receptors of the ECS. Instead, it interacts indirectly not only with the CB1 and CB2 receptors, but also with another receptor related to mood and brain function, the 5HT1-A (3). The 5HT1-A is a serotonin receptor and is found throughout the brain, and in high densities in the cerebral cortex, hippocampus and amygdala – all heavily involved in the mood and anxiety disorders.

Turns out that CBD is a 5HT1-A partial agonist – which in layman’s terms means it binds to the receptor site, but only stimulates the receptor partially – but scientists suggest it does so just enough to elicit an anti-anxiety effect.

Studies also suggest that CBD’s ability to promote hippocampal neurogenesis (the part of the brain responsible for memory, emotion and the autonomic nervous system) could also explain why anxiety is reduced. (4)

And remember the feel good endocannabinoid, Anandamide? Well, taking CBD can also take part in ensuring that we have bountiful levels of it in our bodies. Anandamide is broken down naturally in the body by an enzyme called FAAH (Fatty Acid Amide Hydrolase), but CBD inhibits the production of FAAH, meaning that there’s more anandamide doing its mood-mediating work. (5)


How to Take CBD for Anxiety

There are a range of products made to be administered in different way. Most common are the CBD drops, which are best taken the by sublingual administration, but can also be taken orally, epidermally, and even vaginally or anally (though we suggest using CBD suppositories for this - a whole lot easier). This method has proven to have long-lasting effects and allows the body to metabolise the CBD, delivering relief to where it is needed.

CBD vaping is also a fantastic way to get CBD into your body fast. If you feel a panic attack coming on, vaping CBD is one of the fastest-acting methods of CBD administration, which could mean the difference of having a full blown panic attack or a slight increase in stress. Though a fast and efficient way to get your CBD, it isn’t as long-lasting as other methods and, due to recent investigations into vaping, could actually be harmful. This highlights the importance of you deciding which delivery method works best for you.

There are many other ways of administering CBD - like CBD capsules for swallowing with no earthy flavours, CBD suppositories, CBD oil and pastes, and even ointments and salves - so do your research and find what product may be right for you.

CBD rich Hemp oil


OK, CBD Sounds Amazing – Now What?

CBD, as we know, is a natural cannabinoid found in cannabis, but in most countries, cannabis is illegal because it contains THC – the compound that gets you high. However, CBD can also be found in hemp – which is effectively the same plant as cannabis, only hemp has been cultivated for its super-low levels of THC – which is legal almost everywhere in the world.

As scientific and anecdotal evidence begins to mount, so does the interest for CBD, from consumers to those selling the product. Some unscrupulous companies are beginning to take advantage of the CBD gold rush, so it is vitally important to find a clean, ethically produced source of CBD oil that comes with Organic and GMP (Good Manufacturing Process) certification.

We always recommend that people do their own research, like looking at peer reviews on sites such as Trustpilot. Of course, these only count as further anecdotal evidence, but they are a good indication of the quality of a product and the customer care involved.

A quick glance through Trustpilot also indicates the positive impact that CBD oil has had on the lives of many anxiety sufferers. Here are just a few testimonies reporting their experiences with CBD. People everywhere are relishing the relief CBD has been able to bring them:

  • "Thank you for making a high quality product that has helped with the anxiety and depression that I suffer from"- Sherrie, Endoca customer.
  • "Great product almost seems like an cure all. I got it for stress and anxiety. Which impedes sex with me totally relaxed after taking it. Checked my blood pressure after using your product it’s now in an good range. And the list seems to go on and on…great product" - D.C, Endoca customer.
  • "Have been using the 10 mg CBD Capsule for 6 nights now and have noticed a difference in my ability to fall asleep, less intra-ocular pressure and much less tension in my sterno-clydo-mastoid muscles. I am retired Military and a Vietnam Vet with PTSD. This seems to be lessening my hypervigilance and overall stress" - Michael, Endoca customer.
  • Smooth start with this Cannabidiol. No harsh reactions. Good results with controlling mood and anxiety - Daniel, Endoca customer.

These personal testimonies are not scientific proof of the efficacy of CBD oil for anxiety. Under EU legislation Endoca cannot make any claims about CBD’s medical uses, so if you do decide to take CBD for anxiety, please be sure to inform your doctor or health practitioner, especially if you are taking other medication.

However, we do believe that just around the corner is an unavoidable tipping point waiting to happen, after which there will be no option but the funding of appropriate clinical studies, facilitating a long-awaited integration of mainstream treatment with CBD for anxiety.

We can all be part of that growing critical mass of medical cannabis and create the momentum for change. We’d love to hear about your experiences with CBD and anxiety. Please leave your feedback on Facebook or in the comments section of this blog.



  1. Bergamaschi MM1, Queiroz RH, Chagas MH, de Oliveira DC, De Martinis BS, Kapczinski F, Quevedo J, Roesler R, Schröder N, Nardi AE, Martín-Santos R,Hallak JE, Zuardi AW, Crippa JA. (2011). Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients. Neuropsychopharmacology. 36(6):1219-26
  2. Crippa JA1, Derenusson GN, Ferrari TB, Wichert-Ana L, Duran FL, Martin-Santos R, Simões MV, Bhattacharyya S, Fusar-Poli P, Atakan Z, Santos Filho A,Freitas-Ferrari MC, McGuire PK, Zuardi AW, Busatto GF, Hallak JE.(2011) Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. Journal of Psychopharmacology. 25(1):121-30
  3. Leonardo BM Resstel, Rodrigo F Tavares, Sabrina FS Lisboa, Sâmia RL Joca, Fernando MA Corrêa and Francisco S Guimarães. 5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats. 2009. British Journal of Pharmacology. 156(1): 181–188
  4. Campos AC1, Ortega Z, Palazuelos J, Fogaça MV, Aguiar DC, Díaz-Alonso J, Ortega-Gutiérrez S, Vázquez-Villa H, Moreira FA, Guzmán M, Galve-Roperh I,Guimarães FS.Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. (2013). Journal of Psychopharmacology. 16(6):1407-19.
  5. Bluett RJ, Gamble-George JC, Hermanson DJ, Hartley ND, Marnett LJ, Patel S. Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation. (2014). Translational Psychiatry. 4:e40 1038/tp.2014.53.

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Disclaimer: Views expressed here do not necessarily reflect those of Endoca and its staff. This article is not intended to provide medical advice, diagnosis, treatment or cure. Endoca CBD products have not been approved by the US Food and Drug Administration (FDA).

Endoca© CBD: Mary_Biles

Mary Biles

Mary Biles is a British Writer with a background in TV production and holistic health. Since living in Spain she has written for the BBC, CNN and currently contributes to the Endoca blog, as well as other guest publications like the Huffington Post. Her passion is writing about developments in medical cannabis, cannabinoid research and where possible interviewing the scientists that make these new discoveries.

Mary has seen first hand the healing potential of the cannabis plant and is committed to ensuring that medical cannabis is available to those who most need it.


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